Anti-aging potential of plant-derived compounds in Drosophila melanogaster
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Abstract
The exploration of plant-derived compounds for anti-aging interventions has garnered significant attention, with Drosophila melanogaster serving as a pivotal model organism due to its genetic tractability and conserved aging pathways. Recent studies have highlighted the efficacy of various phytochemicals in modulating lifespan and enhancing stress resistance in Drosophila. Ginseng extract, rich in ginsenosides, has been shown to extend the lifespan of Drosophila by approximately 9.72%. This effect is attributed to the activation of the AMPK pathway and inhibition of the mTOR pathway, leading to improved energy metabolism and stress resilience. Similarly, caffeic acid, a phenolic compound, has demonstrated protective effects against age-associated intestinal dysplasia by suppressing oxidative stress-induced JNK signaling, thereby maintaining intestinal stem cell function. Flavonoids, a diverse group of polyphenolic compounds found in various plants, exhibit potent antioxidant and anti-inflammatory properties. Their role in mitigating oxidative damage and modulating signaling pathways associated with aging underscores their potential as anti-aging agents. The mechanisms underlying the anti-aging effects of these phytochemicals involve the modulation of key genetic pathways, including the upregulation of sirtuins (e.g., SIRT1), activation of AMPK, and suppression of mTOR signaling. These pathways collectively contribute to enhanced autophagy, improved mitochondrial function, and reduced cellular senescence.
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