Evaluating The Clinical Efficacy Of Preimplantation Genetic Screening In Optimizing Ivf Success Rates Under Variable Biological Conditions
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Abstract
Infertility is currently becoming a major health issue in the world with many couples turning to the use of assisted reproductive technologies including In Vitro Fertilization (IVF); the success rates of IVF are however fluctuating as a result of various factors including maternal age, embryo quality and failed attempts of IVF. This paper will assess the clinical effectiveness of Preimplantation Genetic Screening (PGS) in the optimization of IVF outcomes in varying biological settings with the help of a quantitative and comparative research design relying on secondary clinical data. The patients were divided into PGS and non-PGS groups, and the main reproductive outcomes were compared with statistical comparisons on the basis of percentage, such as the implantation rate, clinical pregnancy rate, live birth rate and miscarriage rate. The findings indicate that IVF cycles with PGS have a significantly better implantation rate (68%), clinical pregnancy rate (62%), and live birth rate (58%) and a significantly low miscarriage rate (12%). Moreover, in spite of the decreasing success rates with maternal age and repeated IVF failures, the use of PGS will always improve the results in all categories of cases, as it will enable us to select chromosomally normal (euploid) embryos. Another critical point that the study brings to light is that the quality of embryos is still an essential factor, but genetic screening increases the probability of success even in moderate and poor-quality embryos. The results in general indicate that PGS is a very useful instrument that can be used in enhancing IVF rates, minimizing reproductive risks, and facilitating individualized and evidence-based reproductive treatment plans, especially in cases of high-risk and repeat failures.
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